Endocrine Abstracts

ObjectiveThe aim of the study was to compare the effect of metformin, orlistat and pioglitazone on insulin resistance in patients with polycystic ovarian syndrome.Methods30 overweight PCOS women were recruited using the Rotterdam criteria (mean age (±S.E.M.) 26(±1.5)yrs and body mass index 35.9(±1.3) kg/m2). Fasting blood was collected at the same time each day on 10 c...

Orlistat and Metformin have both been shown to be beneficial in the treatment of Polycystic Ovarian Syndrome (PCOS), however, because Orlistat works by decreasing the absorption of dietary lipids, there is the potential to decrease absorption of lipophilic antioxidant substances with consequent decreased protection from oxidative stress. The objective of this study was to evaluate and compare the effect of treatment with orlistat vs. metformin on oxidative stress in pat...

Objectives: There is strong epidemiological evidence that insulin resistance confers a significantly increased risk of cardiovascular disease independent of other cardiovascular risk factors. The aim of the study is to compare the insulin resistance levels in metabolic syndrome of polycystic ovarian syndrome (PCOS) with that of type 2 diabetes (T2DM).Methods: The biological variation of IR was assessed by measuring IR at four day intervals on 10 consecut...